inhibitory effect of allicin and garlic extracts on growth of cultured hyphae

نویسندگان

farzad aala department of medical mycology & parasitology, school of medicine, kurdistan university of medical sciences, sanandaj, kurdistan, iran

umi kalsom yusuf department of biology, faculty of science, university putra malaysia, selangor, malaysia

rosimah nulit department of biology, faculty of science, university putra malaysia, selangor, malaysia

sassan rezaie department of medical mycology & parasitology, school of public health, tehran university of medical sciences, tehran, iran

چکیده

objective(s): trichophyton rubrum (t. rubrum) is one of the most common dermatophytes worldwide. this fungus invaded skin appendages of humans and animals. recently, resistance to antifungal drugs as well as appearance of side effects due to indication of these kinds of antibiotics has been reported. besides, using some plant extracts have been indicated in herbal medicine as an alternative treatment of these fungal infections. the aim of this study was to investigate the effects of garlic (allium sativum) and pure allicin on the growth of hypha in t. rubrum using electron miscroscopy. materials and methods:this study was carried out to observe the morphological changes of t. rubrum treated with allicin as well as aqueous garlic extract using scanning electron microscopy (sem) and transmission electron microscopy (tem). results: sem surveys, showed that hypha treated with allicin has rough and granular like surface, abnormal and irregularly-shape. however, hypha treated with garlic extract had rough and fluffy surface and also irregularly-shape. tem studies also found that hypha treated with allicin displays disintegration of cytoplasm, breaking down in cell membrane and the cell wall, and collapsing of hypha, meanwhile hypha treated with garlic extract exhibiting degradation and dissolution of cytoplasm components, demolition of cell wall and cell membrane, and hypha appeared to break. conclusion: the present study revealed that pure allicin (6.25 µg/ml and 12.5 µg/ml) is more efficient in inhibition of the growth in hyphal cells compare to the garlic extract (2 mg/ml and 4 mg/ml) and they could be used as alternatives in treatment of dermatophytosis.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Inhibitory effect of allicin and garlic extracts on growth of cultured hyphae

Objective(s): Trichophyton rubrum (T. rubrum) is one of the most common dermatophytes worldwide. This fungus invaded skin appendages of humans and animals. Recently, resistance to antifungal drugs as well as appearance of side effects due to indication of these kinds of antibiotics has been reported. Besides, using some plant extracts have been indicated in herbal medicine as an alternative tre...

متن کامل

Inhibitory effect of allicin and garlic extracts on growth of cultured hyphae

OBJECTIVE(S) Trichophyton rubrum (T. rubrum) is one of the most common dermatophytes worldwide. This fungus invaded skin appendages of humans and animals. Recently, resistance to antifungal drugs as well as appearance of side effects due to indication of these kinds of antibiotics has been reported. Besides, using some plant extracts have been indicated in herbal medicine as an alternative trea...

متن کامل

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Inhibitory Effects of Aqueous Onion and Garlic Extracts on Growth and Keratinase Activity in Trichophyton mentagrophytes

The effect of onion and garlic extracts on fungal growth and keratinolytic activity was studied in Trichophyton mentagrophytes as one of the major etiologic agents of human and animal dermatophytosis in Iran and other parts of the world. In order to find out the best keratinase producer for further steps, culture conditions for 30 strains of T. mentagrophytes isolated from human dermatophytosis...

متن کامل

effect of seed priming and irrigation regimes on yield,yield components and quality of safflowers cultivars

این مطالعه در سال 1386-87 در آزمایشگاه و مزرعه پژوهشی دانشگاه صنعتی اصفهان به منظور تعیین مناسب ترین تیمار بذری و ارزیابی اثر پرایمینگ بر روی سه رقم گلرنگ تحت سه رژیم آبیاری انجام گرفت. برخی از مطالعات اثرات سودمند پرایمینگ بذر را بر روی گیاهان مختلف بررسی کرده اند اما در حال حاضر اطلاعات کمی در مورد خصوصیات مربوط به جوانه زنی، مراحل نموی، عملکرد و خصوصیات کمی و کیفی بذور تیمار شده ژنوتیپ های م...

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۷، شماره ۳، صفحات ۱۵۰-۱۵۴

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023